Are you a glaucoma patient who has been taking eye medication for a long time? Have you ever heard of the saying “three medicines are poisonous”? Do you think this is about those patients who take medication for the whole body, and if you just use some eye medication on your eyes, there will not be much side effects? In fact, topical eye medication can also be absorbed by the body and may produce certain toxicity, plus glaucoma patients often use medication for a long time, the side effects should not be ignored. Below, I describe the side effects of several types of IOP-lowering medications that are currently in common use. After using the pupil-reducing drug Mao Guo Yunxin, patients often have the feeling that they can’t see far away and clear near, and that they can’t see in the dark and clear in the light, and they may have different degrees of periorbital pain, headache and other discomfort; long-term uninterrupted use may also cause permanent narrowing of the pupil; short-term heavy use may even cause sweating, tearing, nausea, vomiting, slow heart rate, hypotension and other symptoms of toxicity and may be life-threatening. Some special patients, such as those with high myopia and previous retinal detachment, may develop retinal fissures, retinal detachment and other fundus abnormalities during use. The use of ophthalmic drugs such as Thimerosal, Meclizine, and Betagen may cause slowed heart rate and induce asthma, and a few patients may also experience drowsiness and weakness, depression, and anxiety. Allergic reactions such as eye redness, eye itching, and itchy eyelid skin may occur with the use of alphagen eye drops. A few patients may also experience a mild drop in blood pressure, fatigue, fatigue, and dryness of the mouth and nose. The side effects of eye pressure medications such as Zolpidem, Suvastan and Lumigan are mainly localized eye redness, eye grinding, eye itching, darkening and thickening of eyelashes, dark circles and darkening of the eye, etc. A few patients may also experience dry eyes, eye pain, eye swelling and other discomforts. Patients who have had cataract surgery or uveitis may also develop inflammatory reactions in the eye and macular lesions in the fundus. Some patients may experience bitterness in the mouth, metallic taste in the mouth, gastrointestinal discomfort, headache, nausea, fatigue, itchy skin rash, etc. In pediatric patients, the use of Pyridoxine may cause burning and stinging sensation in the eyes and transient blurred vision. For pediatric patients, the eye medication used should be reduced in concentration and frequency as appropriate. Apheresis and mauveine are not used or used sparingly, the former may cause drowsiness or even life-threatening in children, and the latter may have some effect on the development of the eye. In addition to the different side effects of different drugs mentioned above, patients who use eye medications for a long time will have some degree of dry eyes such as dry eyes and eye grinding, which require frequent supplementation of artificial tears to moisten the eyes; sometimes allergy symptoms such as eye itching and eye redness will occur, requiring discontinuation or change of medication. In view of these side effects of glaucoma medications, you should pay attention to the following points when using them: before using the medication, try to tell your doctor in more detail about your previous and current diseases so that you can choose the appropriate treatment plan; follow the doctor’s prescriptions and do not increase or decrease the number of medications at will, as the former may increase the side effects of the medication and the latter may lead to insufficient efficacy; compress the root of the inner canthus for 2 to 5 minutes after dropping the medication and close the eyes for 5 to 10 minutes. This will increase the effect of the medication and reduce the systemic absorption, thus reducing its side effects; you need to review the medication regularly, and if some discomfort occurs during the medication process, communicate with the doctor in a timely manner and change the medication or even switch to other treatments if necessary.