Symptoms of late stage lung cancer may vary depending on the patient’s physical condition. The condition is more serious in late stage lung cancer and needs timely symptomatic treatment. Symptoms of locally advanced lung cancer: The thoracic cavity is a very complex space, three-quarters of the lung surface is surrounded by the chest wall, which is composed of a thin layer of lining (wall pleura), fat, muscle, rib cage and skin in different proportions. Tumor invasion of any of these parts will cause pain. Therefore, most of the lung cancer patients with intra-thoracic regional dissemination have symptoms of chest pain. Hoarseness is the most common symptom of advanced lung cancer patients. The laryngeal recurrent nerve, which controls the left side of the articulation function, travels down from the neck to the chest and returns up to the larynx around the large blood vessels of the heart, thus innervating the left side of the articulation organ. Therefore, if the tumor invades the left side of mediastinum, the laryngeal nerve will be compressed and hoarseness will arise, but there are no other symptoms such as sore throat and upper respiratory tract infection. 2.Shortness of breath and pleural effusion Almost all patients with advanced lung cancer who have regional spread have different degrees of shortness of breath. The normal tissue fluid produced by lung and heart muscle is returned by lymph nodes in the middle of chest. If these lymph nodes are blocked by the tumor, this tissue fluid will accumulate in the pericardium to form a pericardial effusion or in the thorax to form a pleural effusion. Both of the above conditions can lead to shortness of breath. In the right side of mediastinum, there is superior vena cava, which transmits the venous blood from upper limbs and head and neck back to heart. If the tumor invades the right side of mediastinum and compresses the superior vena cava, the jugular vein will initially become angry due to poor return flow, and eventually it will lead to facial and neck edema, which needs timely diagnosis and treatment. Metastasis of different organs can occur in the late stage of lung cancer, which can cause corresponding symptoms and often bring great pain to patients and even threaten their lives. (1) Bone metastasis: about 50% of lung cancer patients will eventually develop bone metastasis in multiple locations. Bone metastases are usually asymptomatic in the early stage, but bone isotope scan can detect the lesioned bones. The symptoms of bone metastasis are related to the location and quantity of tumor metastasis. For example, chest pain caused by lung cancer rib metastasis is mostly confined to the chest wall and has clear pressure points. (2) Liver metastasis: liver is also a common metastatic site of lung cancer, with about 28-33% of lung cancer showing liver metastasis. Liver metastasis is the invasion of primary lung cancer cells into the liver through blood circulation after shedding and growing in the liver, and liver metastasis can be single or multiple nodal metastases. The most common symptom is pain in the liver area, which is persistent rising pain, and may be accompanied by loss of appetite, indigestion and other signs of impaired liver function. (3) Brain metastasis: unexplained headache, vomiting, visual disturbance and change in personality and temperament of lung cancer patients may be caused by intracranial hypertension or brain nerve damage caused by lung cancer metastasis to the brain. It is common in small cell lung cancer and adenocarcinoma types. (4) Metastasis to other sites: In addition to the above mentioned common metastatic sites, less common metastatic sites include metastasis to skin, subcutaneous tissue, muscle, intra-abdominal cavity, heart and other sites, and the symptoms are often related to the metastatic sites. For example, metastasis to the heart may cause chest tightness, palpitation or even shortness of breath, syncope, heart rhythm disorder and other symptoms.