Both Prickly Wujia and tonifying the middle Jiaozhong Yiqi Pill can strengthen the spleen and enhance qi, but there is no comparison between the efficacy. Prickly Wujia is the dried root and rhizome or stem of the plant Prickly Wujia, family Wujiaceae. It can benefit qi and strengthen the spleen (regulating the qi of the spleen and stomach), and tonify the kidney and calm the spirit. It is used for spleen and lung qi deficiency, weakness, loss of appetite, lung and kidney deficiency, prolonged cough and asthma, kidney deficiency, lumbar and knee pain, insufficiency of the heart and spleen, insomnia and excessive dreaming. Caution should be exercised in cases of Yin deficiency and internal heat. It is composed of Astragalus (honey-roasted), Codonopsis, Atractylodes Macrocephalae, Angelica Sinensis, Ascophyllum, Radix Bupleurum Chinense, and Pericarpium Citri Reticulatae, which can tonify the middle Jiaozhong and benefit the qi. It is used for body fatigue and weakness, and prolapse of internal organs. The adverse reactions and contraindications of tonifying the middle and benefiting qi pill are not clear at present. Patients are advised to use the medicine under the guidance of a doctor.