From liver fibrosis to cirrhosis, it takes 1-2 years for a short period of time, and decades for a long period of time, because there are individual differences, the exact time cannot be determined. Liver fibrosis refers to the diffuse excessive deposition and abnormal distribution of extracellular matrix (i.e. collagen, glycoproteins and proteoglycans, etc.) in the liver, which is the pathological repair response of the liver to chronic injury, and it is a key step in the development of various chronic liver diseases to cirrhosis and an important link that affects the prognosis of chronic liver diseases. Liver fibrosis is a pathological change that exists in the course of most chronic liver diseases, and it takes 1-2 years to go from liver fibrosis to cirrhosis in a short period of time and decades in a long period of time. In mild liver fibrosis, reversal is possible. If it enters into moderate or severe fibrosis, or even into cirrhosis, there is no possibility of reversal. Therefore, active treatment of liver fibrosis is of great significance to improve the quality of life of patients and improve the prognosis of the disease.