Weight loss can reduce insulin resistance, which refers to a certain amount of insulin that cannot play the corresponding biological role. Insulin is the only hypoglycemic hormone in the body. Under normal circumstances, the body regulates the dynamic balance of blood glucose through insulin and insulin antagonist hormones. When insulin resistance is caused by genetics or obesity, the body will promote insulin secretion to avoid elevated blood glucose, resulting in hyperinsulinemia. When the promoted insulin secretion still cannot control blood glucose at normal level, abnormal glucose tolerance or even diabetic state will appear. Therefore, obesity is an important cause of insulin resistance, and insulin resistance is one of the important reasons for the occurrence of type 2 diabetes. Therefore, effective weight loss and maintenance of ideal body weight can effectively improve insulin resistance and slow down the generation and development of type 2 diabetes.