The differences between acetaminophen and aspirin are as follows: 1. Aspirin is more widely used in clinical practice, in addition to its antipyretic and analgesic effects, the main clinical applications are small doses of aspirin to prevent myocardial infarction, arterial thrombosis, atherosclerosis and other problems; 2. The anti-inflammatory effect of acetaminophen is weaker, and has no effect on platelets and coagulation mechanisms, which is the main difference with aspirin; Acetaminophen is mainly used clinically for colds, fever, arthralgia, neuropathic pain, migraine, and as a pain reliever after some surgeries, as well as for the treatment of cancer pain. Both acetaminophen and aspirin can relieve fever and analgesia, and the principle of their analgesia is roughly the same, both acting on the hypothalamus thermoregulatory center, inhibiting the synthesis of prostaglandins, and causing peripheral blood vessels to expand and sweat to achieve the effect of analgesia.