Patient: My condition was diagnosed on March 26, 2008 with serum prostate-specific antigen t-PSA = 28.13ng/ml, f-PSA = 1.920, f-PSA/t-PSA = 0.07. From July 15, 2010 t-PSA = 39.99, -PSA = 2.150, f-PSA/t-PSA = 0.05 indicators have been increasing. The results of each of my tests are as follows The results of each of my tests are as follows: Year-Month-Day: Item Name PSA, f-PSA, f-PSA/PSA. 2008-03-25: 28.13, 1.920, 0.07. -04-02: 27.46, 1.430, 0.05; -06-03: 28.11, 1.530, 0.05; -06-18. 25.04, 1.650, 0.07; -12-02: 29.21, 1.970, 0.07; 2009-03-10: 35.63, 1.910, 0.05; -06-23: 34.00, 1.910, 0.05 06-23: 34.00, 2.55, 0.07; -10-20: 36.27, 2.66, 0.07; 2010-01-19: 37.94, 2.150, 0.06 0.06; -04-27: 43.28, 2.24, 0.05; -07-15: 39.99, 2.150, 0.05. I was admitted to China-Japan Friendship Hospital on April 11 and decided to have a puncture biopsy procedure. Pathological examination returns: Pathological diagnosis: (prostate puncture specimen 1) highly suspicious of prostate adenocarcinoma, lesions are too small, do immunohistochemistry, deep cuts when the lesions disappear, suggest re-examination. (Prostate puncture specimens 2, 3, 4) The prostate tissue sent for examination showed chronic inflammation and no cancer was seen. Immunohistochemistry: 34BE12 (+), P63 (+), P504s (+). Discharge diagnosis certificate — Clinical diagnosis: 1. Prostatic hyperplasia 2. Prostate adenocarcinoma? (Highly suspicious). I was examined again on June 18 at Peking University First Hospital with PSA of 25.04. MR examination on July 8: MRI: prostate size about 3.5 * 2.6 * 4.4mm. MRS: left central zone of prostate with abnormal metabolite concentration ratio. The diagnosis: it is an abnormal left central zone of the prostate, with a high probability of prostate cancer. I was admitted to Peking University First Hospital from 2008/08/12 to 2008/08/16 (during the Beijing Olympic Games) and was diagnosed with elevated PSA and prostate hyperplasia. What we saw: TRUS prostate examination: prostate 4.9 * 2.8 * 4.3, prostate enlarged, volume 31ml, intact peritoneum, echogenicity not uniform. TRUS-guided prostate systemic biopsy + lesion biopsy: A 13-stitch systemic biopsy of the prostate was performed under TRUS guidance in five areas of the rectum, with a total of 13 tissues taken, and the biopsy went well. The patient had no uncomfortable reaction. Examination conclusion: prostatic hyperplasia TRUS guided prostate biopsy Pathology report card Pathology diagnosis: prostate puncture 13 stitches: prostate tissue, no cancer seen. Discharge summary: final diagnosis: PSA ↑, prostatic hyperplasia. 1. I was born in April 1930 and am now over 80 years old. At present, my nighttime urination is basically normal 2 – 3 times, and there is no painful urination or blood in the urine, but the PSA value has been very high for two years. Please advise, thank you! 2. I am currently diagnosed with prostate enlargement, but my PSA has been elevated, should I have another prostate puncture biopsy for this condition? 3. I want to use conservative treatment and I am not currently taking any medication. Should I or should I take any medication? Please advise. 4. Is there any relationship between diet and age if PSA continues to rise? Please advise, thank you! Reply: Both of your puncture biopsies were negative. However, puncture biopsies are taken at multiple points, so if the tumor is small, it may still be missed, so it should be monitored closely. The PSA is not unanimously classified as prostate cancer, because PSA is only a specific indicator of the prostate, chronic inflammation can also be elevated, only your elevation is more pronounced than ordinary inflammation. If you are not sure of the diagnosis, there is no good way to prevent it, so you are advised to relax and live a regular life, in addition to regular rechecking. As for whether to puncture again, it depends on the results of the review.