The desire to vomit after staying up late is mainly due to the following reasons: First, if the patient is middle-aged or elderly, after staying up late for a long time, it is easy to cause elevated blood pressure, mostly in patients with previous hypertension, increased blood pressure, more than the brain’s own blood volume regulation, it is easy to cause hypertensive encephalopathy nausea, vomiting. Second, after staying up late nausea, vomiting, if it is a young patient, ask the patient whether there is dizziness, and long-term sleep deprivation, it is easy to appear dizziness, nausea, vomiting. Third, nausea and vomiting after staying up late, if it is an elderly patient with risk factors such as diabetes, heavy smoking, obesity, hyperlipidemia, etc., and nausea and vomiting appear, consider the possibility that the patient has an acute cerebrovascular attack, such as cerebral infarction, cerebral hemorrhage, and needs to go for MRI examination. Thirdly, if some patients have vomiting after staying up late, ask them if they have a history of heartburn and chest tightness, there are some patients with atypical myocardial infarction who show symptoms of nausea and vomiting after staying up late.