If fasting blood uric acid is >420umol/L in men or postmenopausal women and >360umol/L in premenopausal women on two non-same days, it is called hyperuricemia. Above this concentration, urate is deposited in the tissues and causes a variety of damage to the body, and is a high risk factor for kidney disease, diabetes, hypertension, hyperlipidemia and cardiovascular disease. You need to start uric acid-lowering treatment if you have any of the following conditions: i. Blood uric acid ≥ 420umol/L in men or ≥ 360umol/L in women, combined with cardiovascular disease or cardiovascular risk factors, such as hypertension, hyperlipidemia, diabetes, coronary heart disease, etc. Second, blood uric acid ≥ 420umol/L (men) or ≥ 360umol/L (women), no cardiovascular risk factors, after 3 months of lifestyle intervention, blood uric acid still does not meet the standard. Third, uric acid ≥ 540umol/L, regardless of the presence of cardiovascular risk factors, start uric acid-lowering treatment. IV. Acute attack of gout, while treated with adequate anti-inflammatory drugs. V. Anti-inflammatory therapy for chronic arthritis.