Weakness of limbs can be differentiated and diagnosed with electrolyte disorders related diseases, neurological diseases and endocrine diseases. 1. Electrolyte disorders related diseases: such as hypokalemia, refers to blood potassium <3.5mmol/L, common clinical manifestations include limb weakness, anorexia, nausea and vomiting and other discomforts. 2. Neurological diseases: such as acute cerebral infarction, when the lesion involves bilateral cerebral hemispheres or brainstem, it can be manifested as weakness of limbs, speech impediment and so on. 3. Endocrine diseases: commonly seen in hypoglycemia, weakness of limbs can be accompanied by palpitations, hunger and other clinical manifestations, but also seen in hypothyroidism, can also appear symptoms of weakness of limbs. In daily life, if the weakness of the limbs occurs and continues without relief, it is recommended to go to a regular hospital to avoid delaying the condition.