Hepatitis B patients check platelet count reduced to 90 × 10 ^ 9 / L, is suggestive of hepatitis B patients occurring portal hypertension appeared signal, need to be actively treated. Hepatitis B virus infection is the most important cause of cirrhosis in China, hepatitis B virus gradually destroys hepatocytes, leading to chronic inflammation of the organs, diffuse fibrosis, and ultimately cause portal hypertension and hepatic decompensation. Normal platelet count is (100-300) × 10^9 / L, the patient’s platelet count at this time has been lower than normal, suggesting that the patient has occurred portal hypertension, with the aggravation of splenomegaly, hypersplenism, white blood cell count will further decline. In addition, the decrease in platelet count suggests that the patient may have entered the decompensated stage of cirrhosis. With the gradual aggravation of portal hypertension and hepatic decompensation, the patient often dies due to the complication of esophagogastric fundal variceal hemorrhage, hepatic encephalopathy, and hepatorenal syndrome. For the treatment of hypersplenism that causes a decrease in platelet count, partial splenic artery embolization and transjugular intrahepatic portacaval shunt are the main treatments. In addition patients must undergo protection, improvement of liver function and treatment of portal hypertension, and anti-hepatitis virus treatment by antiviral drugs such as tenofovir. Hepatitis B patients should go to the Department of Infectious Diseases or the Department of Gastroenterology as soon as a decrease in platelet count is detected during a physical examination and follow the doctor’s instructions for treatment.