Rheumatism and gout differ in etiology, clinical symptoms, and laboratory tests. Gout is mainly caused by hyperuricemia, which is associated with a disorder of purine metabolism and/or hyperuricemia caused by decreased uric acid excretion. Rheumatic diseases are a group of diseases, mostly autoimmune, that primarily invade the joints, bones, muscles, blood vessels, and related soft or connective tissues. Rheumatism still lacks specific laboratory tests, clinically commonly used blood sedimentation, rheumatoid factor, autoantibodies and other tests; gout often check the blood uric acid index. Rheumatism is mainly knee, shoulder and lumbar pain, symmetrical joint involvement. Gout mainly involves a single joint, commonly the first metatarsophalangeal joint, often in the middle of the night attack, usually joint redness, swelling, heat and pain, pain is intense, the clinical display of blood uric acid concentration is very high. It is recommended that the patient go to the hospital in time, to clarify the diagnosis, and follow the doctor’s instructions for active treatment.