Irbesartan hydrochlorothiazide tablets may cause creatinine rise, but mostly occur in people with renal artery stenosis. Irbesartan in Irbesartan Hydrochlorothiazide Tablets is an angiotensin-converting enzyme inhibitor, the drug, in addition to antihypertensive effect, there is dilation of glomerular inlet and outlet small arteries (dilatation of the action of the outlet > inlet), reduce intraglomerular high pressure, hyperperfusion, high filtration state, reduce urinary protein and delay the deterioration of renal function. Renal artery stenosis, the blood supply to the kidneys is reduced, when the use of the above drugs, expansion of the glomerular arteries out of the glomerulus on the basis of blood flow from the entry arteries into the glomerulus and then reduced, further reducing the blood supply to the kidneys, renal ischemia will appear after the decline in renal function, creatinine increased. Therefore, the drug is prohibited for people with double renal artery stenosis. Irbesartan hydrochlorothiazide tablets are antihypertensive drugs, it is recommended to use under the guidance of a doctor, not blindly oral and adjust the dose.