Intrahepatic bile duct stones, also known as hepatobiliary stones, are common and difficult to treat biliary tract diseases in China and are an important part of primary bile duct stone disease. It mainly refers to stones that occur above the confluence of the left and right hepatic ducts. Its etiology is complex, mainly related to biliary tract infection, biliary parasitism, bile stasis, bile duct anatomical variation, malnutrition, etc. The clinical manifestations of intrahepatic bile duct stones are very atypical. They can be asymptomatic for many years or only have epigastric and thoracic back distension and discomfort. Most patients are found incidentally during physical examination or ultrasonography for other diseases. During the interval of the disease, the symptoms are atypical and are often misdiagnosed as chronic dyspepsia, gastric disease, etc. However, in the acute phase, it often presents as chills, high fever and abdominal pain caused by acute cholangitis, and when obstruction occurs it will manifest as jaundice. Long-term obstruction can even lead to cirrhosis, which manifests as jaundice, ascites, portal hypertension and upper gastrointestinal bleeding, and liver failure. Recurrent cholangitis can lead to multiple liver abscesses, with pressure and percussion pain in the liver area on physical examination, and in a few cases, an enlarged or asymmetrical liver can be palpated. Because of its complex lesions, high recurrence rate and often serious complications, this disease is an important cause of death from benign biliary disease in China.