Tacrolimus is recommended to be taken on an empty stomach, 1 hour before or 2-3 hours after a meal, the exact time of taking should depend on the patient’s specific condition, there is no so-called “best” time. Tacrolimus is generally recommended to be taken on an empty stomach, one hour before or two to three hours after a meal. Food can lead to a decrease in the absorption of tacrolimus, especially high-fat foods. In order to ensure greater absorption of tacrolimus, it is often taken on an empty stomach. However, the specific clinical time of taking should be based on the patient’s specific condition. Tacrolimus is a macrolide antibiotic and an immunosuppressant. It is mainly used for the treatment of rejection reaction after organ transplantation, atopic dermatitis, systemic lupus erythematosus and other immune diseases. This product can cause infections, diarrhea, nausea, hyperglycemia, insomnia, headache, hypertension and other adverse reactions. This product is contraindicated in people who are allergic to the drug. Take care to monitor blood pressure, electrocardiogram, neurological and visual status, fasting blood glucose, electrolytes (especially blood potassium), hepatic and renal function tests, hematological parameters, coagulation values, plasma proteins, etc. during the administration of the drug. If you need to take tacrolimus, it is recommended to go to the hospital in time, actively cooperate with the doctor’s treatment plan, follow the doctor’s instructions, do not blindly take the drug by yourself.