Sacubitril valsartan sodium tablets can be replaced with angiotensin-converting enzyme inhibitors such as enalapril, or angiotensin II receptor conjugate antagonists such as valsartan. Sacubitril valsartan sodium tablets, mainly used for chronic heart failure with reduced ejection fraction, can reduce the mortality rate of cardiovascular disease, clinically with β-blockers, diuretics, aldosterone receptor antagonists can be used together, the side effects of angioedema, hypotension, etc., is prohibited in patients with mid-term and late pregnancy. Angiotensin-converting enzyme inhibitors can be used instead of sakubutra valsartan sodium tablets, such drugs have the effect of improving myocardial remodeling and lowering blood pressure, and when used in the clinic, note that elevated potassium and bilateral renal artery stenosis can not be taken, and the most common side effects with this type of drug are dry cough, and angioneurotic edema and allergy can also occur. Valsartan and other drugs can be used instead of Sacubitril valsartan sodium tablets, which can effectively reduce the level of blood pressure, this type of drug relative to angiotensin-converting enzyme inhibitors, fewer side effects, resulting in angioneurotic edema, allergic reactions and so on less often. Clinical use of attention to the above two drug components or excipients allergic patients can not take, pregnant, lactating women can not take. For patients with heart failure, it is recommended to consult the cardiovascular department of regular hospitals.