Oral leukoplakia may become cancerous. Oral leukoplakia belongs to pre-cancerous lesions or potential malignant diseases, and there is a certain risk of cancer. 1. At present, the important indicators for predicting the risk of cancerous transformation of oral white spots are the presence of abnormal proliferation and the degree of abnormal proliferation through pathological examination. Comparatively speaking, the risk of cancer is higher in the warty, granular and ulcerated types of oral leukoplakia. 2. In addition, patients with Candida infection, HPV infection, patients with a long course of the disease, patients with lesions located on the tongue margin, tongue belly, inner triangle of the mouth corner, and patients with lesions larger than 200mm² in area are also at a higher risk of cancer. If a diagnosis of oral leukoplakia is made, it is recommended that regular follow-up visits to the hospital be made and, if necessary, multiple biopsies be performed.