Long-term late night, all-nighters will cause activation of the renin-angiotensin system, leading to increased blood pressure, long-term hypertension is likely to cause stroke, angina attack. Long-term late night, all-nighters are also prone to coronary atherosclerosis, leading to coronary heart disease, unstable angina pectoris, serious acute myocardial infarction, which can lead to sudden death. Long-term late night, all-nighter is easy to cause neurasthenia, autonomic dysfunction, can also cause sudden death. So avoid staying up late for a long time to avoid cardiovascular disease and reduce the possibility of sudden death, and usually arrange work and rest.