Nikethamide [Alias] Coramine. [Application] It is a medullary excitatory drug with strong effect on respiratory center and some degree of excitatory effect on vasomotor center. Used for central respiratory and circulatory failure, narcotics and other central depressants poisoning relief.
[Dosage] Subcutaneous injection, static injection or intramuscular injection: 0.25~0.5g/time, extreme 1.25g/time.
[Side effects] High doses may cause increased blood pressure, palpitations, sweating, vomiting, tremor and muscle rigidity.
[Precautions] (1) In case of side effects, stop the drug promptly to prevent convulsions. (2) If convulsions occur, inject benzodiazepines or small doses of thiopental sodium intravenously.
[Formulation specification] Injection: 0.375g/1ml. Lobeline [Alias] Lobeline.
[Application] It excites the carotid chemoreceptors and reflexively excites the respiratory center. Used in neonatal asphyxia and respiratory failure caused by various diseases.
[Dosage] Subcutaneous or intramuscular injection: adults 3~10mg/dose, extreme 20mg/dose, 50mg/day. Children 1~3mg/dose. Intravenous injection: adults 3mg/dose, extreme 6mg/dose, 20mg/day. Children 0. 3~3mg/dose.
[Side effects] High dose may cause tachycardia, conduction block, respiratory depression, and even convulsions.
[Precautions] The injection should be slow.
[Preparation specification] Injection: 3mg/1ml. Bemegride [Alias] Megimide. [Application] Central stimulant, antagonistic to barbiturates and other ophthalmic drugs. It is used to relieve barbiturates, chloral hydrate poisoning, etc. It is also used to accelerate the recovery from thiopental sodium anesthesia.
[Dosage and Administration] Intravenous: the usual amount of 0.5% 10ml (50mg), diluted with 5% glucose and then intravenous. Intravenous injection: 50mg every 3~5min until the condition improves or symptoms of poisoning appear.
[Side effects] Large or too fast injection may cause nausea, vomiting, enhanced reflexes, muscle tremors and convulsions. Late onset of toxicity is emotional disturbance and mental confusion.
[Precautions] Short-term barbiturates should be prepared for rescue in case of convulsions.
[Preparation] Injection: 50mg/10ml. Caffeine and Sodium Benzoate [Alias] Sodium benzoate. CSB, CNB. [Application] Small doses enhance the cortical excitation process, and larger doses excite the respiratory and vasomotor centers of the medulla oblongata. It is used for central respiratory and circulatory insufficiency and recurrent apnea in newborns.
[Dosage] Intramuscular or subcutaneous injection: 0.25~0.5g/dose, extreme dose, 0.75g/dose, 3g/day.
[Side effects] Palpitations, extrasystole, polyuria, muscle tremor.
[Precautions] Use with caution in neonates with hyperbilirubinemia.
[Formulation] Injection: 0.5g/2ml. Dimefline [Alias] Kaisuline.
[Application] Strong central respiratory excitatory effect. It is used for central respiratory failure caused by various reasons, respiratory depression caused by anesthetics and hypnotics, and deficiency and shock caused by trauma and surgery.
[Dosage] Intramuscular injection: 8mg/dose. Intravenous injection: 8mg/dose, diluted with glucose solution. IV: 8~16mg/time, diluted with saline or glucose solution.
[Side effects] Nausea, vomiting, burning sensation of skin, etc. Excessive dose may cause muscle tremors, convulsions, etc.
[Precautions] (1) Short-acting barbiturates should be prepared for convulsive first aid. (2) The speed of sedation should be slow. (3) Forbidden for people with history of convulsions, hepatic and renal insufficiency and pregnant women.
[Preparation specification] Injection: 8mg/2ml.