Patients with intermediate stage of invasive esophageal cancer need to choose treatment modalities such as surgery, radiotherapy and chemotherapy according to their specific conditions. Intermediate stage of esophageal cancer mainly means that the cancer cells have developed metastasis in lymph nodes around the esophagus, such as mediastinal lymph node metastasis and lymph node metastasis around the cardia. However, there is no metastasis to distant organs. It is necessary to choose the treatment mode according to the site of cancer and the patient’s general condition. If there is an indication for surgery and the patient can tolerate the surgery, the patient can choose the surgery, and after the surgery, the patient can choose radiotherapy or chemotherapy according to the patient’s condition, expecting to have a long term survival. It is recommended that patients go to regular hospitals and receive standardized treatment under the guidance of doctors.