In addition to the general physical examination, the pre-pregnancy examination includes routine blood and urine tests, hepatitis B surface antigen, and tests for some specific pathogens. Chromosome testing should be performed where available to avoid hereditary diseases. If the male exposure to radiation, chemicals, pesticides or high temperature work, etc., may affect the reproductive cells; found abnormal, or advised not to have children, or although fertile but it is advisable to timely treatment, or although fertile should pay attention to some of the problems, so that both parties in the best state of health to get pregnant. Thus effectively control and prevent congenital diseases and fetal malformations, reduce the rate of birth defects, in order to protect the health of infants. The seriously ill children not only have physical defects, while often prone to low self-esteem, this physical and mental defects in the disease are not conducive to their future healthy growth. 1, sick first treatment Pregnancy is no less than a “war” in the body, if the fetus is likened to the “front”, the mother is the “rear”, the umbilical cord is the “line of communication”. The umbilical cord is the “line of communication”. As the saying goes: “before the army moves, food and grass first”, body anemia, equivalent to the grain harvest; body infection, equivalent to the warrior infected; platelet deficiency, equivalent to the defective fortifications, at this point in time to start the war, will not be able to win a great victory? So we have to check first, have a disease first treatment, plan and then move. Medicine is three times poisonous, some pregnant need to continue to take drugs to control the disease, the fetus may have adverse effects. 2, basic control After pregnancy, the body will undergo a series of changes. Some are physiological changes, such as an increase in white blood cells, a decrease in red blood cells, a slight decrease in albumin, an increase in blood lipids, an increase in subcutaneous fat, mild swelling, weight gain; some are pathological changes, such as an increase in blood glucose, an increase in blood pressure, a significant decrease in red blood cells, severe swelling, no increase in body weight or a significant increase. This requires a general understanding of the pre-pregnancy situation, such as what is the baseline blood pressure? What is the baseline weight? This is conducive to the doctor to make a correct judgment on the changes in pregnancy and its clinical significance. 3, eugenics family planning is a basic state policy in China, the state advocates a couple to have only one child, which makes eugenics very important. The three pre-tests (pre-marriage, pre-pregnancy, prenatal) are specific measures for eugenics, which are of great significance in reducing birth defects, improving population quality and ensuring the safety of mothers and infants. For example, folic acid supplementation during the perinatal period (the three months before and after pregnancy) can reduce the risk of the development of anencephaly, spina bifida, cerebrospinal bulge, and some congenital heart diseases, and is one of the means of first-level prevention of birth defects, especially for expectant mothers and daughters who have had deformed children. By preventing and reducing diseases and realizing a harmonious and happy well-off family, we can build a well-off society, construct a harmonious society, improve the quality of the population, and realize the comprehensive, coordinated and sustainable development of human beings and society.