Summary of Prevention of High Lead Hematology and Lead Poisoning in Children (Reprint)

1, the nail seam is particularly easy to hide the parts of the lead dust. Songyuan City Hospital of Traditional Chinese Medicine pediatrics Ning Peng 2, shopping for children’s tableware should avoid colorful patterns and shoddy products. Children should be avoided to eat eggs and old-fashioned popcorn machine popping food and other food containing high lead.3, fasting and food excessively greasy will increase the intestinal absorption of lead.4, high-lead anemia: two consecutive venous blood lead level of 100 ~ 199mg / L; lead poisoning: two consecutive venous blood lead level is equal to or higher than 200mg / L; and based on the level of blood lead is divided into light, medium and severe lead poisoning. Mild lead poisoning: blood lead level is 200~249mg/L; moderate lead poisoning: blood lead level is 250~449mg/L; severe lead poisoning: blood lead level is equal to or higher than 450mg/L; children’s lead poisoning can be accompanied by some non-specific clinical symptoms, such as abdominal pain, constipation, anemia, hyperactivity, impulsivity, etc.; blood lead is equal to or higher than 700mg/L, can be accompanied by coma, When the blood lead is equal to or higher than 700mg/L, it can be accompanied by coma, convulsions and other manifestations of lead poisoning encephalopathy.5. Exclusion and detachment from the source of lead contamination is the fundamental way to deal with the children’s high-lead anemia and lead poisoning.6. Lead expulsion treatment is only used for children with blood lead level in moderate and above lead poisoning.7. Attention should be paid to the treatment of lead expulsion: ① Make sure that you detach from the source of contamination before you use oral lead expulsion medication, or it will result in the increase of the absorption of lead in the digestive tract. Iron-deficient children should be supplemented with iron before lead repellent treatment, because iron deficiency will affect the effect of lead repellent treatment. 8, the specific method of lead repellent test is as follows: Before the test, the child should be instructed to empty the bladder, and then intramuscularly injected with calcium sodium edetate at a dose of 500-700mg/m2 of body surface area, and 2ml of 2% lidocaine should be added to minimize the pain of the intramuscular injection. The urine was collected continuously for 8 hours with a lead-free vessel, and the 8-hour urine volume (L) and urine lead concentration (mg/L) were measured, and the lead displacement ratio I per milligram of calcium edetate sodium was calculated by the following formula, I = urine volume (L) × urine lead concentration (mg/L)/calcium edetate sodium (mg) I ≥ 0.6 is considered as a positive test for the lead repellent test, and I < 0.6 is considered as a negative test for the lead repellent test. Two issues should be noted when performing this test: (1) Urine collection vessels should be lead-free beforehand to ensure accurate urinary lead measurements. (2) Drink as much water as possible during the 8 hours to ensure sufficient urine volume, and collect all the urine during the 8 hours.9 Lead repellent treatment is preferred to dimercaptosuccinic acid (DMSA). Dosage: 350mg/m2 (body surface area) or 10mg/(kg.d) per time, 3 times a day orally for 5d, then change to 2 times a day with the same dosage each time for 14d. Each course of treatment is totaled to 19d. For the children who can not be completely detached from the environment contaminated with lead, they should be treated with calcium sodium edetate, with the dosage of 1000 (moderate)-1500 (severe) mg/m2 (body surface area), and collect all the urine within 8 hours. The dosage is 1000 (moderate)-1500 (severe) mg/m2 (body surface area), injected intravenously or intramuscularly, and the course of treatment is 5d. After stopping the drug for 2-6 weeks, review the blood lead, if ≥450ug/L can repeat the above treatment program; if 2 consecutive reviews of blood lead <450ug/L and ≥250ug/L, according to the treatment of moderate lead poisoning. If the blood lead mass concentration is ≥700ug/L, the venous blood lead should be rechecked immediately, and the child should be hospitalized in a hospital capable of treating the disease after confirmation. According to the child's medical history, oral ingestion should exclude the large amount of lead contaminant mercaptan residue in the digestive tract, and give enema and gastric lavage if necessary. Combined treatment with DMSA and calcium sodium edetate is used. Combined treatment should first be treated with DMSA for 4h, and when the child appears to urinate, then calcium sodium edetate can be used, otherwise it is easy to lead to lead poisoning encephalopathy. Liver and kidney function, water electrolytes and other indicators should be tested during treatment. Review the blood lead after the end of combined treatment, if ≥700ug/L can immediately repeat the combined treatment program, if ≥450ug/L, according to the treatment of severe lead poisoning. After 3 consecutive courses of lead expulsion treatment, blood levels of iron, zinc, calcium and other trace elements should be tested and supplemented in time. The effect of treatment should be closely observed. There is little experience in the treatment of neonatal lead poisoning.