There is no “best” treatment for grade 3 breast nodules, and the choice of follow-up, medication, or surgery depends on the nature of the nodule. The classification of breast nodules is based on the assessment of the risk of benign or malignant nodules based on the imaging findings, of which grade 3 is highly likely to be benign, with a probability of malignancy of <2%. Grade 3 breast nodules are more likely to be caused by benign breast diseases, if the nodule is caused by breast hyperplasia, generally take drugs such as tamoxifen for symptomatic treatment; if the nodule is caused by acute mastitis, it can be treated with penicillin and other antibiotics to fight infections, and incision and drainage is feasible after the formation of abscesses. In case of fibroma and intraductal papilloma, surgical excision of the lump is usually required. Grade 3 nodules also have a smaller risk of being malignant tumors such as breast cancer, which require radical surgery, chemotherapy, endocrine therapy, and other comprehensive treatments. Patients are advised to consult a specialist to determine the etiology of the nodule and follow the doctor's instructions for further examination and treatment.