Azotemia is a biochemical term that has both broad and narrow concepts. The broad concept is that any non-protein nitrogen such as urea nitrogen or creatinine in the blood that exceeds the normal range can be called azotemia. A variety of kidney diseases that do not heal, late renal impairment can occur, so that the nitrogen excretion in the blood is impaired, so the accumulation in the blood, which is the result of renal failure. The study shows that smoking can promote the progression of chronic kidney disease, so patients with kidney disease are encouraged to quit smoking; obesity is recommended to lose weight, which can effectively reduce the production of proteinuria. A high quality low protein, low phosphorus, low fat diet, symptomatic hypotension, hypoglycemia, correction of acid-base imbalance, control of infection, correction of anemia and other conventional treatments were given. Add Tong tonic granules, the composition of the formula: party ginseng, astragalus, atractylodes, poria, rehmannia, cuscuta, fried dulcimer, oyster, rhubarb, huang lian, sand, fenugreek, cocos ling, dan shen, motherwort, roasted licorice. Dosage: 2 sachets (5g/bag) each time, 1 time in the morning and 1 time in the evening, after meals, taken with boiled water or swallowed. 2 months is a course of treatment. Chronic renal failure belongs to the category of “edema”, “deficiency labor”, “Guange” and “retention of urine” in Chinese medicine. This disease is the evidence of deficiency and mixed deficiency. The deficiency includes deficiency of qi, blood, yin and yang, mainly in the spleen and kidney; the deficiency includes dampness and turbidity, water and qi, blood stasis, and may be accompanied by dampness and turbidity into heat, sometimes with external evil.