Treatment for high rheumatoid factor varies depending on the cause. High rheumatoid factor may be associated with autoimmune diseases such as rheumatoid arthritis, dry syndrome, and systemic lupus erythematosus, and the main treatments for these diseases include general therapy and medication. Other causes such as infections and tumors also need to be treated. 1. General treatment: Rheumatoid arthritis should be based on bed rest, and joint functional exercise should be started as early as possible during the remission period, and the amount of exercise should be measured. For the dry mouth symptoms of dry syndrome, one should replenish water, keep the mouth clean, keep the air moist, and use alternatives such as artificial tears. SLE should pay attention to rest and sun protection. 2. Drug therapy: autoimmune disease needs to start anti-inflammatory and immunity-regulating therapy, such as non-steroidal anti-inflammatory drugs, such as indomethacin, ibuprofen, diclofenac, etc.; biologics, such as TNF antagonists, IL-6 receptor antagonists, etc.; glucocorticosteroids, such as prednisone; and traditional anti-rheumatic drugs to improve the condition, such as methotrexate, sulphasalazine pyridine, anti-malarials. 3. Other causes: infections and tumor diseases can also lead to high rheumatoid factor, and should be targeted anti-infection or anti-tumor therapy. High rheumatoid factor also needs to be combined with the characteristics of the medical history, other test results to make an accurate judgment, it is recommended that patients under the guidance of a doctor to clarify the cause of the disease should actively cooperate with the treatment, do not use their own medication, so as to avoid delaying the condition or adverse reactions.