Metformin and gliclazide are not comparable, belonging to two different types of hypoglycemic drugs, can not say which one is fast, there are indications that patients are recommended to take medication under the guidance of a doctor. 1. Metformin: mainly through the improvement of insulin sensitivity to reduce fasting and postprandial glucose, and economic cheap, generally suitable for simple dietary control is not satisfied with type 2 diabetes mellitus patients, especially obese and with hyperinsulinemia. 2. Gliclazide: the mechanism of action is to promote the body’s secretion of insulin, so that insulin to further reduce blood glucose, suitable for dietary control and physical exercise for 2-3 months unsatisfactory effect of light, moderate type 2 diabetes (non-insulin-dependent diabetes) patients, the pancreatic β-cells have a certain degree of secretion of insulin function. The two have different mechanisms of action, can be used in combination, that is, the patient can eat metformin, gliclazide at the same time, individualized medication, the two with each other or any one of them alone can be a smooth control of blood glucose is the effect is good. When patients with elevated blood glucose, they can choose hypoglycemic drugs under the guidance of the doctor, active treatment.