Diuretics, beta blockers, ACEIs, and ARBs are the four classes of drugs that do not cause edema. The common ones are: furosemide, metoprolol, enalapril, and chlorosartan. Taking high blood pressure medication edema is due to the adverse reaction of the drug, common drugs are: nifedipine extended-release tablets, amlodipine benzenesulfonate tablets and so on. In most cases, edema occurs in the lower limbs, because these drugs achieve the purpose of lowering blood pressure by dilating blood vessels, so it will slow down the blood circulation in the lower limbs, resulting in blood stagnation and ultimately triggering edema. Do not panic, go to the hospital as soon as possible, explain the situation to the doctor, usually will change the patient’s antihypertensive drugs, calcium channel antagonists for drugs without edema adverse effects.