HFMD is a category C infectious disease and requires isolation after illness. HFMD is an infectious disease caused by enteroviruses, mostly in children, and the common enteroviruses are coxsackie A16 and the new enterovirus 71. After contracting HFMD, children can develop symptoms such as rash, oral herpes, fever, anorexia, nausea, vomiting, headache, easily startled, and sleep disturbance. Depending on the severity of the disease, it is recommended to visit the hand, foot and mouth clinic of the local infectious disease hospital for relevant tests, including laboratory tests and electrocardiogram or electroencephalogram, as well as chest X-ray. According to the test results, follow the doctor’s prescription for reasonable symptomatic treatment.