Hand, foot and mouth disease is an acute infectious disease caused by an enterovirus and characterized by fever and rash on the hands, feet and mouth. If the patient has severe itching at night, it may be combined with the possibility of secondary infection, and can follow medical advice to apply mupirocin ointment for anti-infection treatment, and at the same time should pay attention to good rash care. Patients should brush their teeth in the morning and evening, and rinse their mouth with warm water or saline before and after eating to keep their mouth clean. For severe herpes and ulcers in the mouth, use saline before and after eating or use medical mouthwash to apply to the affected area or gargle as prescribed by the doctor. You can also use vitamin B2 powder or make a paste of montmorillonite and put it on the ulcerated surface with a cotton swab after meals. In the early stage of hand and foot rash when the herpes is not broken, it can be treated by applying furnace glycolate lotion or sodium bicarbonate solution. When there is herpes formation or herpes breaks down, treatment can be applied with iodophor. Herpes on the buttocks can be applied locally with erythromycin ointment and cod liver oil to relieve pain and prevent infection. Patients should eat a light diet, supplement nutrition, and eat regularly and quantitatively, with easy-to-digest, liquid or semi-liquid food, such as milk, thin gruel, egg custard, etc. Clothes and bedding should be clean, comfortable and soft, and changed frequently. Avoid cleaning the skin with soap and shower gel.