The hot burning sensation on the fingertips may be caused by contact with certain irritating substances, or it may be caused by certain diseases, such as allergies, carpal tunnel syndrome peripheral neuritis, etc., and you should consult a doctor in time to find out the cause. 1. Contact with substances: If the fingertips come into contact with certain irritating substances, such as chili peppers, strong acids and alkalis and other chemicals, which irritate the skin, symptoms such as hot and burning sensation will occur, usually after thorough cleaning the symptoms can be relieved. 2. Allergy: hot burning sensation in the fingertips may be an over-immune reaction caused by skin contact with certain allergens, which may be accompanied by itching, rash, swelling and other skin allergic reactions, and in severe cases, anaphylactic shock may also occur, which may even be life-threatening. 3. Carpal Tunnel Syndrome: Carpal Tunnel Syndrome is a syndrome caused by the compression of the median nerve in the carpal tunnel. Patients may experience numbness and swelling of the fingers, accompanied by burning pain, usually at night, in the morning, or when the symptoms worsened by exertion. 4. Peripheral neuritis: peripheral neuritis can be caused by mechanical compression, poisoning, infection, inflammation and other factors, early patients can appear pins and needles, burning, tenderness and other sensory symptoms, with the development of the disease, can cause symmetrical superficial sensory loss or disappearance of the limbs. Fingertips appear hot burning sensation, should consult the doctor in time, clear diagnosis, if necessary, the corresponding treatment.