Activating macrophages does not produce collagen. Macrophages are immune cells belonging to the immune system, with the function of swallowing and processing large foreign objects, old waste excreted by cells, normal apoptotic red blood cells, etc., but do not have the function of producing collagen, so activating macrophages cannot produce collagen. Collagen is a class of protein family, is the main component in the connective tissue of animals, and is widely distributed in all tissues of the human body. Collagen is mainly synthesized from proteins and amino acids in the body. Moderate supplementation of proteins and amino acids can promote the production of collagen to a certain extent, but the effect is also limited. In summary, activation of macrophages is not associated with collagen production, so the claim that activation of macrophages can produce collagen does not exist.