The most effective treatment for lipomas that occur in the axilla subcutaneously is surgery, usually under local anesthesia, to remove the lesion completely. If the lipoma is large, intravenous anesthesia can be used if necessary to minimize the patient’s pain. The special anatomy of the armpit means that it takes a long time for the incision to heal, and it is even prone to secondary subcutaneous fluid accumulation, so care should be taken to squeeze the wound during each change of medication. If there is fluid accumulation, it should be promptly eliminated and appropriate oral anti-infective medication, commonly used is penicillin v potassium tablets, or you can also choose roxithromycin capsules, and pay attention to local hygiene during treatment. If local gauze is found to be soaked with sweat or there is bloody exudation, it should also be promptly changed by disinfection, changing sterile gauze as well as dressings and performing local re-dressing.