Taking entecavir for 3 months, the virus may have its replication curbed, or the effect may not be obvious, there are no special circumstances need to continue to take, or adjust the medication according to the situation. Entecavir is an effective antiviral drug, but it can’t kill the virus, only curb the replication of the virus, and its course of treatment is relatively long, usually need to take a year or longer. After one year, 70% of patients have a negative hepatitis B DNA test. Generally take three months time is short, less than the course of treatment, it is difficult to judge the efficacy, some patients at this time the efficacy is not obvious, but most of the patients at this time the amount of viral replication began to decline. It is recommended that if there are no obvious side effects and the virus has decreased to a certain extent, you can continue to take it to see the results.