As we age, all human systems will inevitably age, and naturally so will the reproductive system, especially the female reproductive system. Relevant information shows that the probability of female infertility: 20-24 years of age about 5.7%, 25-29 years of age about 9.3%, 30-34 years of age about 15.5%, 35-39 years of age about 29.6%, 40-44 years of age about 63.5%, 44 years of age and beyond the age of 87% of women suffering from infertility. Generally speaking, 23 to 30 years old is the golden age of female fertility, beyond this age, female fertility begins to decline, especially after 35 years old, women’s oocyte quality and quantity declined significantly, the ovarian reserve function, the embryo implantation rate and the clinical pregnancy rate all appear to be reduced; and genetic abnormalities of the embryo and fetus incidence and miscarriage rate, etc. increased. Therefore, the problem of eugenics in the senior population becomes more pronounced, and many women of advanced age seek the help of assisted reproductive technology. However, obtaining high-quality oocytes is the basic guarantee for the success of assisted reproductive technology, so age also has a great influence on the outcome of assisted reproductive technology. I. Ovarian Reserve Capacity and Age Ovarian reserve refers to the number of primordial follicles present in the ovarian tissue, and is an important indicator of a woman’s fertility; as she ages, the number of eggs remaining will become smaller and smaller, and so will her ovarian reserve. In addition, ovarian responsiveness refers to the ability of ovarian follicles to respond to changes in endogenous or exogenous hormone levels, and is a prerequisite for the development, maturation, and ovulation of eggs, as well as for obtaining a sufficient number of eggs and high quality eggs for IVF. Clinical observation shows that ovarian reserve capacity and ovarian responsiveness are highly correlated with age, i.e., as age increases, ovarian reserve capacity and ovarian responsiveness gradually decrease. Intrauterine environment and age The stability of the intrauterine environment is necessary to promote embryonic development, including endometrial tolerance, normal morphology of the uterine cavity and appropriate uterine tension. Endometrial tolerance is mainly affected by the thickness of the endometrium, tissue structure and blood flow. With age, the endometrium undergoes a series of morphological and functional changes, including an increase in collagen content, a decrease in estrogen and progesterone receptors in the endometrial cells, and a decrease in the volume of endometrium undergoing metamorphosis and in uterine blood flow. And this series of changes have caused great difficulties for the embryo landing and development. Third, the embryo quality and age The birth of female germ cells means a gradual aging, young women around 20 years of age discharged oocytes only 2-3% of chromosomal abnormalities, while at the age of 40 years, this risk increases to 30-35%. Age increases the incidence of errors in the first and second meiotic divisions of the oocyte. Decreased egg quality and increased chromosomal abnormalities are manifested in delayed and arrested development of the preimplantation embryo, increased likelihood of mental retardation or fetal malformations, and significantly higher rates of mid-pregnancy miscarriages. Therefore, age has a very great impact on women’s fertility, whether it is natural conception or IVF, choosing the optimal age for fertility is the most scientific. You can’t blindly think that IVF can be successful no matter what your age is. Statistics from large samples at home and abroad show that the carryover rate of IVF at age 45 or above is extremely low, usually no more than 2%, so many fertility centers no longer do IVF for patients over 45. On the other hand, the risks of pregnancy for both the mother and the fetus are increased in advanced age, the chances of maternal hyperemesis, gestational diabetes are greatly increased, and the possibility of difficult labor and premature birth will also rise, and from the point of view of the child, the probability of genetic disorders and autism will also increase, and in addition to some congenital disorders increase in the incidence of the disease. Therefore, giving birth at the right age is also most conducive to women’s own physical recovery and the realization of eugenics. As you can see, IVF is not something that can be done at any age. IVF treatment at the right age not only has a higher success rate of transplantation, but also reduces pregnancy complications and results in healthier offspring.