The causes of nodular pimples with hard lumps may include acne, folliculitis, dermatofibroma, etc. The methods of softening include drug therapy and surgery. 1. Acne: If the nodules are caused by Acinetobacter acnes, antibacterial treatment such as mupirocin and fusidic acid can be given, and photoelectric treatment such as fractional laser can also be considered after eliminating relevant contraindications. 2. Folliculitis: If bacterial infection of hair follicles leads to acne hard lumps, then you can use topical mupirocin ointment, compound polymyxin b and other anti-infection treatment. 3. Dermatofibroma: for patients with evidence of dermatofibroma, this time can be given polysulfated mucopolysaccharide cream softening treatment, if the effect is not good can be surgical excision. Finally, the phenomenon of nodular acne hard lumps please consult a doctor, the above drugs must follow the doctor’s instructions.