The causes of dry and rough hands are dry skin, ichthyosis, chronic eczema, vitamin deficiency, etc., which can be improved through enhanced care and medication. 1. dry skin: if long-term in a hot and dry environment, the skin will lose water, thus showing the symptoms of dry and rough hand lines, such patients should pay attention to avoid frequent hand washing, the use of hand cream and other lotion to help moisturize, but also can use hand film to help improve the overly dry skin of the hands. 2. Ichthyosis: genetic factors, malnutrition, etc. will affect the skin keratinization, damage the skin barrier, causing abnormal proliferation of skin cells, shedding, so that the patient appears hand dry rough lines more performance; can be applied locally urea cream, vitamin A cream and other drugs to increase the skin absorbent, to improve the degree of keratinization, the serious need for oral vitamin A or vitamin A acid and other medications to help treatment. 3. Chronic eczema: endocrine abnormalities, immune abnormalities and other factors can lead to chronic eczema, often manifested as local skin roughness, hypertrophy, itching, mossy changes and other symptoms, repeated episodes can lead to patients appearing hand dry roughness and more lines; such patients can be applied topically to the Dinocaprolactone cream, tacrolimus ointment and other medications to help the treatment, and if necessary, oral cloxacillin and other drugs. 4. Vitamin deficiency: when patients have vitamin B1, B3 and other vitamin deficiencies, the hands do not get adequate nutrition, which may appear hand dry rough lines and other symptoms; can take vitamin complex to improve the symptoms. There are many reasons for hand dryness and roughness, it is recommended to consult a doctor in time and follow the doctor’s instructions to standardize the treatment.