Arterial phase perfusion insufficiency is an arterial angiography test that refers to poor contrast development at the time of arterial filling after contrast is injected into the arteries. It is usually indicative of a slowing of blood flow in the arteries, which may occur because of arterial plaque formation, arterial stenosis, or poor arterial elasticity, which prevents the arteries from filling in time for the cardiac ejection of blood, so that the arterial phase perfusion is suboptimal. If arterial hypoperfusion occurs during a coronary CTA of the heart, it suggests the possibility of coronary artery stenosis or a decrease in the heart’s pumping capacity, resulting in a slowing down of intra-arterial blood flow. If arterial hypoperfusion occurs during a cerebral angiogram, it can indicate cerebral stenosis, which can lead to severe cerebral infarction. Regarding the clinical significance of arterial hypoperfusion, it should be judged in conjunction with the specific site of examination. When arterial hypoperfusion occurs, it is necessary to consult a doctor in a timely manner and standardize the treatment under the guidance of a specialist.