Callus on the hand may be due to friction and pressure caused by the normal physiological phenomenon, may also be common warts, ringworm and other disease factors lead to local skin lesions similar to callus. 1. Normal physiological phenomenon: hand local skin long-term friction and pressure, such as long-term fixed hand labor, long-term writing, etc., will lead to excessive skin keratin hyperplasia, manifested as a thick yellow plaque, generally do not need treatment, should pay attention to the hand skin moisturizing, but if there is a tactile abnormality, it is recommended to seek medical attention in a timely manner. 2. common warts: a benign proliferative disease caused by human papillomavirus infection, common in the fingers, the back of the hand and other parts, can be the size of a broad bean pimple, gray or light brown, rough surface, hard texture, can be a single hair can also be more, may also be fused into a plaque. 3. ringworm: due to fungal infections leading to skin diseases, commonly found in the interphalangeal, palm and other parts of the hand, can be manifested as blisters, flaking and other symptoms, long-term infection may appear local skin roughness, thickening, discoloration and other symptoms. Calluses on the hands may also be caused by other factors, it is recommended to exclude physiological factors, timely medical treatment, in order to clarify the cause of the disease, targeted treatment.