Glutamyl transpeptidase 129 U/L is high, whether it is serious or not needs to be judged comprehensively, if it is due to short-term fatigue or drinking a lot of alcohol and other factors, then it is generally not too serious, follow the doctor’s instructions to protect the liver treatment. However, if there is underlying liver disease, a comprehensive judgment is needed. Higher glutamyl transpeptidase may be caused by physiological reasons, such as strenuous exercise or drinking a lot of alcohol before the examination, which will lead to a transient increase, at this time, if the glutamyl transpeptidase is 129U/L, most of the time do not need to take special treatment, and will gradually return to normal in a week or so, which is not serious. If necessary, liver-protecting drugs such as silymarin can be added, and review is recommended after one week. If it is caused by pathologic reasons, such as cirrhosis, fatty liver, liver cancer, bile duct obstruction, etc., it tends to be more serious, and may lead to further progression of the disease if treatment is not taken in time. Glutamyl transpeptidase 129 U/L is abnormal, but it should be combined with other indicators of liver function to reflect and assess the overall situation, and should not be relied upon to determine the severity of the disease. You should cooperate with your doctor to do further examination, and take treatment or therapy after clear diagnosis.