Aspirin is widely used for primary and secondary prevention of ischemic cardiovascular diseases, and the correct way to take it is to minimize the damage to the gastric mucosa. I conducted a survey during four scientific presentations last year and the knowledge rate on this issue was so low that sometimes no one in the audience could answer correctly. Aspirin enteric tablets should be taken on an empty stomach because they are not dissolved when the acidity of the stomach is high and dissolve in an alkaline environment when they are emptied into the duodenum. For these reasons, it is recommended that aspirin be taken on an empty stomach in the morning after waking up, about 30 minutes after the drug is discharged into the intestine and breakfast is appropriate. It is also considered convenient to take it in the evening, but it is necessary to ensure that it is fasting, and it is not advisable to rest in bed immediately after taking it, and it is appropriate to rest after the drug is discharged into the intestinal tract. In short, the only way to minimize the damage of aspirin to the gastric mucosa is to try not to give aspirin the opportunity to dissolve in the stomach. This article is published with the authorization of Dr. Zhiwei Gao.