Drinking alcohol cannot relieve toothache, wine belongs to a kind of beverage, does not have the role of pain relief. Toothache may be caused by dental caries, endodontitis and wisdom tooth pericoronitis, etc., and it can be treated by oral medication, local rinsing, filling, root canal treatment and extraction as prescribed by the doctor. 1. Dental caries: In the early stage of dental caries, patients will not feel obvious pain, but when the cavity becomes deeper and deeper, it will lead to unbearable pain in the teeth. Patients can follow the doctor’s instructions to take silver nitrate and sodium fluoride and other drugs to relieve, but also can use composite resin filling surgery to fill the teeth. 2. Pulpitis: It is common in periodontal tissue disease or dental caries, which leads to periodontal tissue infection and thus inflammation. If the patient needs to save the affected tooth, root canal treatment can be done as prescribed by the doctor. 3. Wisdom tooth pericoronitis: Wisdom tooth pericoronitis can be manifested as toothache, accompanied by swelling and pain in the soft tissues around the wisdom tooth, difficulty in opening. Patients can follow the doctor’s instructions to use saline and hydrogen peroxide for rinsing, and at the same time under the guidance of the physician oral amoxicillin and metronidazole tablets for treatment, if repeated episodes, it is recommended that the tooth extraction. Patients with toothache symptoms attack, should go to the hospital in a timely manner, drinking alcohol can not relieve toothache, to avoid delaying the condition caused by adverse consequences.