We know that some incorrect ways do not make us healthier, but instead can upset our own balance and lead to inflammation of the vagina and other gynecological diseases. So, why can a small microbial imbalance lead to disease? What is the relationship between vaginal micro-ecological imbalance and the pathological state of the vagina? What should we do if there is an imbalance? I. Vaginal micro-ecological imbalance and diseases 1. Relationship between vaginal micro-ecological changes and HPV infection before treatment of cervical lesions In normal female vagina, there are more than 50 kinds of microorganisms, in addition to the most famous Lactobacillus and Bifidobacterium, of course, there may also be viruses, and under normal circumstances, the virus that women are most concerned about and the most harmful at the same time —- cervical cancer killer high risk HPV virus, should normally test negative. In recent years there have been a number of scientific research projects established and some studies published about the relationship between vaginal flora dysbiosis and HPV infection. Studies on HPV viruses and vaginal dysbiosis have shown that high-risk HPV viruses combined with bacterial infections are up to 70%, and that the presence of large numbers of vaginal lactobacilli significantly reduces HPV detection rates, finding that HPV infection rates increase more markedly as the degree of cervical lesion increases and lactobacilli decrease. Bacterial vaginitis is highly associated with HPV infection and promotes its further development. Whether viral invasion leads to the development of inflammation or inflammation predisposes to viral invasion, although there is no definite conclusion, mixed infections can be more detrimental to viral self-clearance and affect the state of the vaginal-cervical environment in the long term. This shows that the vaginal micro-ecology of cervical lesions, whether malignant or non-malignant, has changed, and the long-term dysbiosis of the vaginal flora will also react on the cervix, leading to an increase in the rate of HPV infection, exacerbating the lesions and even worsening them, forming a vicious circle in the long run. Therefore, many people will take the data written in books and copy them, instead of assessing the patient’s overall situation comprehensively, judging lighter cases more seriously, and assessing heavier cases less seriously. 2. Vaginal microecological disorders and reproductive tract infections Under normal conditions, Lactobacillus coexists with other microorganisms in the vagina in a state of microecological balance. Lactobacillus inhibits the adhesion of pathogenic microorganisms by producing lactic acid; its production of H2O2 has a direct bactericidal effect and inhibits the overgrowth of pathogenic bacteria; its large number, accounting for 95% of the population, forms a competitive space occupancy, all of which can inhibit the growth of pathogenic bacteria. Once the former loses its advantage, the latter overgrowth will break this balance, the normal flora can also cause disease, become a conditional pathogenic bacteria, leading to disease. When the relative number of lactic acid bacteria decline, some pathogenic bacteria will be waiting for the opportunity to move. Such as Escherichia coli, bacillus-like bacteria, digestive cocci, Staphylococcus aureus, group B streptococcus, pseudofilamentous yeast, trichomonas and mycoplasma, etc.. Depending on the etiology and pathogens, common vaginitis include: bacterial vaginosis, Candida vaginitis (mycosis fungoides), trichomonas vaginitis, non-gonococcal vaginitis, non-specific vaginitis, senile (or atrophic) vaginitis and viral vaginitis, etc. More than 50% of vaginitis are mixed infections. Methods and measures to restore normal vaginal micro-ecological environment Identify the problem → understand the problem → solve the problem. We probably understand the basic concept of vaginal micro-ecology and have a preliminary knowledge of its pathogenic principles, what can we do when vaginal micro-ecological disorders occur? Or what can we do to prevent it from happening is the next point, which is divided into five main points: 1. This is an old-fashioned concept, which does not mean that it is old, but proves to be classic and necessary. 2, the reasonable application of broad-spectrum antibiotics and hormones. Now the number of people who are concerned about medical science has increased, look at more will naturally know more, many times will feel that they are half a doctor, in the cold, fever and other minor illnesses occur, their own medical treatment has become the most convenient way to solve the problem, here it is easy to occur indiscriminate use of antibiotics, antibiotics is a “sword” is also a “fool”. “It has no ability to distinguish, and while it kills harmful bacteria, the beneficial flora is also badly damaged, and there is often feedback from patients in the clinic that mycosis vaginalis can recur after taking medicine for a cold, which is the reason. 3. Promote showering and avoid unnecessary vaginal douching. Many bacterial and viral infections occur in places with large crowds, humid environments and poor hygiene, and viruses are more serious than bacteria. The flow of water washing has been fully capable of daily cleaning requirements of the skin, we really can not get dirty where. Some women who are highly clean like to douche their vagina with lotion regardless of vaginal abnormalities. This action can lead to an increase in vaginal pH, which is detrimental to the growth of lactic acid bacteria and disrupts the normal balance. Therefore, it is not surprising that you can develop vaginitis while douching every day in pursuit of cleanliness. The more serious result can lead to pelvic inflammatory disease, ectopic pregnancy, premature birth and other gynecological diseases. 4. Do not wear tight underwear, pay attention to menstrual hygiene and keep your vulva clean. The tight panties are wrapped too tightly, not to mention how harmful they really are to the body, and even the different materials of the panties can have an impact on the reproductive system. The actual fact is that you can find a lot of people who are not comfortable with the idea of wearing tight-fitting underwear, but only you know how uncomfortable it is, so why bother? In the period should choose sanitary napkins, do not consider tampons. We have done a comparison experiment between the two and found that the vaginal flora of women who applied tampons and sanitary napkins, the number of coagulase-negative staphylococci in the vagina increased in women who used tampons during menstruation. 5. Replenish Lactobacillus and restore the dominance of Lactobacillus, which is the key to maintain the vaginal microecological balance. Imbalance of vaginal flora can lead to diseases due to changes in flora structure. The dominance of lactobacilli is a prerequisite for vaginal health. When its dominance changes, it triggers the appearance of various uncomfortable complaints, such as abnormal vaginal discharge, odor, vulvar itching and burning, which can lead to various vaginal infections. At present, the most commonly used drug to adjust the micro-ecological environment is Lactobacillus live bacteria preparation, which can quickly restore the number of vaginal Lactobacillus and fundamentally restore the micro-ecology to achieve the therapeutic effect, which is beneficial to women’s health. As to whether the patient is lactobacillus-deficient or not, the dosage and duration of use of lactobacillus preparations need to be diagnosed by the doctor after understanding the patient.