Kidney stone to the bladder mouth does not hurt after two days and then hurt again may be related to the stone blocking the bladder mouth, stone embedded in the urethra, complication of cystitis and other reasons. 1. When the stone blocks the bladder opening, it can cause urine discharge obstruction, acute urinary retention, and bladder distension and pain can occur. 2. If the stone is embedded in the urethra, it can cause smooth muscle contraction and painful symptoms. 3. Bacteria can attach to the stones that stay in the bladder, easily inducing urinary tract infections, leading to cystitis and painful symptoms. It is recommended that kidney stones to the bladder mouth does not hurt after two days and pain in the crowd in a timely manner to the regular hospital, a clear cause, under the guidance of the doctor standardized treatment, so as not to delay the condition.