The causes of baby sleep spitting up have physiological factors and pathological factors, pathological factors include congenital megacolon, pyloric obstruction and other reasons, should be clear reasons, the cause of treatment. 1. Physiological factors: the baby’s digestive system is not perfect, the stomach is horizontal, feeding the baby too much milk, too fast, the baby is too anxious to eat milk or breastfeeding inhalation of large amounts of air and so on will cause the baby to spit up in his sleep, is a physiological factor. 2. Congenital megacolon: congenital megacolon has constipation, spitting up, abdominal distension and other symptoms, should consult a doctor in a timely manner, under the guidance of professional doctors to give treatment. 3. Pyloric obstruction: pyloric obstruction is prone to delayed gastric emptying, too much stuff in the stomach, increased gastric pressure, there will also be the phenomenon of babies spitting up in their sleep. The baby sleep spitting up can be timely medical care, identify the causes, for pathological spitting up, by professional doctors to diagnose the cause of the disease, the treatment of its original disease, relieve the symptoms of spitting up.