The occurrence of bitter mouth in H. pylori quadruple therapy is considered to be related to the side effects of drugs and bile reflux. It is necessary to treat the symptoms according to different causes. 1. Side effects of drugs: H. pylori quadruple therapy drugs, including omeprazole, amoxicillin, clarithromycin, colloidal bismuth pectin, etc., of which clarithromycin will cause changes in the sense of taste, with obvious side effects such as bitter taste in the mouth and loss of appetite. If you can tolerate it, you can insist on completing a course of antibacterial treatment. If you can’t tolerate it, you can replace clarithromycin with antimicrobial drugs such as ofloxacin and minocycline to complete the treatment, or stopping the drug halfway through the treatment can’t completely eradicate H. pylori infection. 2. Bile reflux: H. pylori infection can cause gastritis, decreased gastric motility, the main symptoms of bile reflux, indigestion, bad breath, etc., and in the process of treatment may also cause a bitter taste in the mouth. For the bitter mouth caused by bile reflux, domperidone and mosapride can be applied to enhance gastric motility and reduce reflux, and magnesium aluminum carbonate adsorbs bile, thus reducing the bitter mouth phenomenon. Helicobacter pylori may cause gastritis, gastric ulcers, duodenal ulcers and other digestive diseases, and even cancer, the cause of this disease must be removed. Helicobacter pylori quadruple therapy, during the medication appeared bitter mouth phenomenon, should consult a doctor in a timely manner, follow the doctor’s instructions for symptomatic treatment.