Taking progesterone to keep the fetus in labor will not cause a false-positive Down’s syndrome result. Progesterone, as a birth control medication, does not affect Down’s syndrome results. Down screening is a test in which pregnant women are tested with ultrasound, blood tests such as human chorionic gonadotropin to determine the chances of their fetus having Down syndrome, and to assess which pregnant women need further invasive diagnostic tests. Human chorionic gonadotropin, alpha-fetoprotein, and estrogen in the blood can affect the Down’s syndrome results, and the age of the pregnant woman is also an important factor in the Down’s syndrome results. Progesterone can supplement the insufficient endogenous progesterone secretion, which has no effect on the results of the Down screening, and usually does not cause false-positive Down screening results. Progesterone may have adverse reactions such as nausea and vomiting after taking it, and it should not be used for people with severe liver or kidney insufficiency, and it is recommended that it be used under the guidance of a doctor. Down’s syndrome screening is a result calculated by using comprehensive indicators. If there is a false positive, further tests, such as non-invasive DNA test and amniocentesis test, are needed. It is recommended to undergo Down syndrome screening in a regular hospital to reduce the chance of false positives.