In the middle of the night, the stomach upward reflux choking the respiratory tract is mostly considered to be caused by gastroesophageal reflux disease or excessive secretion of gastric acid, which can be relieved by general treatment, drug treatment, surgical treatment and so on. 1. General treatment: patients can drink some warm water in moderation to dilute the concentration of gastric acid, promote gastrointestinal peristalsis and reduce the symptoms of reflux. Usually, patients should pay attention to diet, avoid eating cold, spicy and other stimulating foods and barbecue and other indigestible foods, avoid overeating, quit smoking and drinking, so as not to stimulate the secretion of gastric acid. At the same time, patients should avoid lying down immediately after meals, and should also avoid eating a lot of food before going to bed, so as not to lead to increased secretion of gastric acid at night. The head of the bed can be raised 15-20 centimeters when sleeping. 2. Drug treatment: patients can take acid-suppressing drugs (such as omeprazole, lansoprazole, etc.) to reduce the secretion of gastric acid and lower the concentration of gastric acid in the stomach; take pro-dynamic drugs (such as domperidone, mosapride, etc.) to promote gastric acid emptying from the stomach and alleviate the reflux; patients with gastric mucous membrane or esophageal mucous membrane damage can also take mucous membrane protective agents (such as bismuth potassium citrate, bismuth pectin, etc.). 3. Surgery: If the patient’s symptoms are severe and cannot be effectively controlled by medication, or if the patient is unwilling to take long-term medication, surgery can also be considered. If the patient has long-term or recurrent gastric regurgitation in the middle of the night choking the respiratory tract, it is recommended to consult a doctor in a timely manner and actively receive treatment. Drugs should be taken in strict accordance with the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition.