The mechanism of action of recombinant human brain natriuretic peptide includes vasodilatation, diuresis, and inhibition of RASS system, etc. The main indication is acute heart failure. Recombinant human brain natriuretic peptide has the effect of vasodilatation, through the dilation of blood vessels to reduce the volume of return blood, can increase the perfusion of the kidneys, increase the diuretic effect, reduce the load on the heart, play the role of anti-heart failure. It is also able to inhibit the RASS system that leads to heart failure, improve the body’s internal environment, and inhibit ventricular remodeling, which is also an aspect of the treatment of heart failure. Recombinant human brain natriuretic peptide, mainly used in the treatment of patients with acute heart failure, is pumped continuously mainly through an intravenous pump, and should be combined with other anti-heart failure drugs, such as diuretics and anti-arrhythmic drugs. Adverse reactions of recombinant human brain natriuretic peptide include dizziness, headache, hypotension, cardiac arrhythmia, deterioration of renal function, etc. It is contraindicated in patients who are allergic to the components of the drug and have severe hypotension. Recombinant human brain natriuretic peptide should be used in strict compliance with the instructions of the physician, and blood pressure levels should be monitored during the use of the drug.