Bile reflux after cholecystectomy usually cannot be completely self-cured. Bile reflux after cholecystectomy is usually caused by organic lesions, usually due to pyloric dysfunction, chronic biliary tract diseases, etc. Patients may experience symptoms such as acid reflux, bitter taste in the mouth, dry mouth, nausea, vomiting, etc., which cannot be completely cured due to the change of physiological structure after the resection surgery. Patients can usually use omeprazole, mosapride and other drugs under the guidance of the doctor for treatment, after the use of patients may experience diarrhea, abdominal pain, dry mouth, dizziness and other symptoms, gastrointestinal bleeding, intestinal obstruction or perforation of the person who prohibit the use of this drug. Patients should maintain a good diet in daily life, prohibit spicy stimulation, greasy food, and go to the hospital for regular review.