Patient: Description of condition (onset, main symptoms, hospital visited, etc.): I am 52 years old with atrial fibrillation, treated with warfarin, with bleeding spots on my body when it is not normal, and when it is adjusted to normal values, the bleeding spots go down, and then normal values, low values or stopping the drug, sometimes with bleeding spots, sometimes without, no other symptoms and reactions. There is no treatment, so please give medical advice from experts. Hong Jiang, Department of Cardiology, Shanghai First People’s Hospital: Warfarin is an important drug to prevent stroke in patients with atrial fibrillation. The drug must be tailored to the individual, and generally the international standardized ratio should be adjusted to between 2-3, with good anticoagulation and less chance of bleeding. Pay attention to bleeding tendencies during anticoagulation with warfarin. A little bleeding spot should be observed intensively.